A Cell-Enriched Engineered Myocardial Graft Limits Infarct Size and Improves Cardiac Function

A Cell-Enriched Engineered Myocardial Graft Limits Infarct Size and Improves Cardiac Function

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Myocardial infarction (MI) remains a dreadful disease around the world, causing irreversible sequelae that shorten life expectancy and reduce quality of life despite current treatment.Here, the authors engineered a cell-enriched myocardial graft, composed of a decellularized myocardial matrix refilled with adipose Soft Toy tissue-derived progenitor cells (EMG-ATDPC).Once applied over the infarcted area in the swine MI model, the EMG-ATDPC improved cardiac function, reduced infarct size, attenuated fibrosis Portable Vaporizers progression, and promoted neovascularization of the ischemic myocardium.

The beneficial effects exerted by the EMG-ATDPC and the absence of identified adverse side effects should facilitate its clinical translation as a novel MI therapy in humans.